Drug interactions
Fluphenazine + Salmeterol
Severity: Moderate
Fluphenazine and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine can prolong the QT interval, and high-dose salmeterol may add to this effect and lower potassium. This may increase the risk of ventricular arrhythmia in susceptible patients.
What this interaction means in plain words
Fluphenazine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Salmeterol belongs to Respiratory.
Why it happens
Additive QT prolongation and beta-2 agonist induced hypokalemia.
What to do
Monitor ECG and potassium in patients with cardiac risk factors, and correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Salmeterol?
MediHelp rates the interaction as moderate. Fluphenazine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine can prolong the QT interval, and high-dose salmeterol may add to this effect and lower potassium. This may increase the risk of ventricular arrhythmia in susceptible patients.
How serious is the interaction between Fluphenazine and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and potassium in patients with cardiac risk factors, and correct electrolyte abnormalities.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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