Drug interactions
Fluphenazine + Scopolamine
Severity: Moderate
Fluphenazine and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine has moderate anticholinergic activity and combined with scopolamine can cause additive dry mouth, constipation, urinary retention, blurred vision and confusion. Scopolamine is also sedating, and may slow gut motility enough to change oral absorption.
What this interaction means in plain words
Fluphenazine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Scopolamine belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade and sedation, with possible reduced oral absorption from slowed gastric motility.
What to do
Monitor for anticholinergic effects and for loss of antipsychotic control. Use the lowest effective doses, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Scopolamine?
MediHelp rates the interaction as moderate. Fluphenazine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine has moderate anticholinergic activity and combined with scopolamine can cause additive dry mouth, constipation, urinary retention, blurred vision and confusion. Scopolamine is also sedating, and may slow gut motility enough to change oral absorption.
How serious is the interaction between Fluphenazine and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and for loss of antipsychotic control. Use the lowest effective doses, especially in older patients.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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