Drug interactions
Fluphenazine + Selegiline
Severity: Moderate
Fluphenazine and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is a dopaminergic MAO-B inhibitor, so it pharmacologically opposes fluphenazine's dopamine blockade, which may worsen parkinsonism or psychosis. Rare serotonergic toxicity or neuroleptic malignant syndrome is also possible.
What this interaction means in plain words
Fluphenazine and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between dopamine agonism and D2 receptor blockade, with possible serotonergic effects.
What to do
Monitor motor symptoms and psychiatric status, and watch for fever, rigidity and agitation. Consider a low-dopamine-blocking antipsychotic in Parkinson's disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Fluphenazine with Selegiline?
MediHelp rates the interaction as moderate. Fluphenazine and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selegiline is a dopaminergic MAO-B inhibitor, so it pharmacologically opposes fluphenazine's dopamine blockade, which may worsen parkinsonism or psychosis. Rare serotonergic toxicity or neuroleptic malignant syndrome is also possible.
How serious is the interaction between Fluphenazine and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor symptoms and psychiatric status, and watch for fever, rigidity and agitation. Consider a low-dopamine-blocking antipsychotic in Parkinson's disease.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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