Drug interactions
Fluphenazine + Sorafenib
Severity: Moderate
Fluphenazine and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combination may increase the risk of torsades de pointes, especially with electrolyte abnormalities.
What this interaction means in plain words
Fluphenazine and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Sorafenib belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes periodically. Correct potassium and magnesium and consider an alternative antipsychotic if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Sorafenib
Frequently asked questions
Can I take Fluphenazine with Sorafenib?
MediHelp rates the interaction as moderate. Fluphenazine and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combination may increase the risk of torsades de pointes, especially with electrolyte abnormalities.
How serious is the interaction between Fluphenazine and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes periodically. Correct potassium and magnesium and consider an alternative antipsychotic if QTc lengthens.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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