Drug interactions
Fluphenazine + Sunitinib
Severity: Moderate
Fluphenazine and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so giving them together may raise the risk of torsades de pointes and other ventricular arrhythmias. The risk is higher with electrolyte disturbances, bradycardia or existing heart disease.
What this interaction means in plain words
Fluphenazine and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Sunitinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation through cardiac potassium channel (hERG) effects.
What to do
Obtain a baseline ECG and repeat it after starting or changing doses, and correct potassium and magnesium abnormalities. Consider an alternative if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Fluphenazine with Sunitinib?
MediHelp rates the interaction as moderate. Fluphenazine and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so giving them together may raise the risk of torsades de pointes and other ventricular arrhythmias. The risk is higher with electrolyte disturbances, bradycardia or existing heart disease.
How serious is the interaction between Fluphenazine and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it after starting or changing doses, and correct potassium and magnesium abnormalities. Consider an alternative if the QTc becomes markedly prolonged.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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