Drug interactions
Fluphenazine + Trandolapril
Severity: Minor
Fluphenazine and Trandolapril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine has some alpha-blocking activity that may add to the blood pressure lowering effect of trandolapril. The effect is usually mild but may cause dizziness on standing.
What this interaction means in plain words
Fluphenazine and Trandolapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluphenazine belongs to Central Nervous System; Trandolapril belongs to Cardiovascular.
Why it happens
Additive hypotension from phenothiazine alpha-blockade and ACE inhibition.
What to do
Check orthostatic blood pressure after starting or increasing either drug and counsel patients to rise slowly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Trandolapril?
MediHelp rates the interaction as minor. Fluphenazine and Trandolapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluphenazine has some alpha-blocking activity that may add to the blood pressure lowering effect of trandolapril. The effect is usually mild but may cause dizziness on standing.
How serious is the interaction between Fluphenazine and Trandolapril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check orthostatic blood pressure after starting or increasing either drug and counsel patients to rise slowly.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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