Drug interactions
Fluphenazine + Tretinoin
Severity: Minor
Fluphenazine and Tretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines can cause photosensitivity and systemic tretinoin may do likewise, so skin reactions to sunlight may be additive. The effect is generally mild and manageable.
What this interaction means in plain words
Fluphenazine and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluphenazine belongs to Central Nervous System; Tretinoin belongs to Dermatology.
Why it happens
Additive photosensitizing effects.
What to do
Counsel on sun avoidance, protective clothing and sunscreen, and report skin reactions.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Fluphenazine with Tretinoin?
MediHelp rates the interaction as minor. Fluphenazine and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazines can cause photosensitivity and systemic tretinoin may do likewise, so skin reactions to sunlight may be additive. The effect is generally mild and manageable.
How serious is the interaction between Fluphenazine and Tretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sun avoidance, protective clothing and sunscreen, and report skin reactions.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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