Drug interactions
Flurazepam + Melatonin
Severity: Moderate
Flurazepam and Melatonin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam is a long-acting benzodiazepine hypnotic whose active metabolites persist for days. Adding melatonin may increase sedation and residual morning impairment, raising the risk of falls and accidents.
What this interaction means in plain words
Flurazepam and Melatonin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression via different pathways (GABA-A modulation and melatonin receptor agonism).
What to do
Avoid unnecessary concurrent hypnotics and use the lowest effective doses, especially in older adults. Counsel on next-day impairment and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Flurazepam with Melatonin?
MediHelp rates the interaction as moderate. Flurazepam and Melatonin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam is a long-acting benzodiazepine hypnotic whose active metabolites persist for days. Adding melatonin may increase sedation and residual morning impairment, raising the risk of falls and accidents.
How serious is the interaction between Flurazepam and Melatonin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary concurrent hypnotics and use the lowest effective doses, especially in older adults. Counsel on next-day impairment and driving.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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