Drug interactions
Flurazepam + Mirtazapine
Severity: Moderate
Flurazepam and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both mirtazapine and flurazepam cause sedation, and flurazepam has long-acting active metabolites. Together they can cause marked next-day drowsiness, impaired coordination, falls and respiratory depression.
What this interaction means in plain words
Flurazepam and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A potentiation and histamine H1 antagonism.
What to do
Use the lowest effective doses and avoid long-term combined use where possible. Monitor for daytime sedation and falls, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Flurazepam with Mirtazapine?
MediHelp rates the interaction as moderate. Flurazepam and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both mirtazapine and flurazepam cause sedation, and flurazepam has long-acting active metabolites. Together they can cause marked next-day drowsiness, impaired coordination, falls and respiratory depression.
How serious is the interaction between Flurazepam and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and avoid long-term combined use where possible. Monitor for daytime sedation and falls, especially in older patients.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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