Drug interactions
Flurazepam + Modafinil
Severity: Moderate
Flurazepam and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam is a long-acting sedative-hypnotic whose effects oppose the wakefulness promotion of modafinil. Modafinil is not a reliable antidote for benzodiazepine-induced impairment, and the combination makes therapeutic goals conflicting.
What this interaction means in plain words
Flurazepam and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic CNS effects; modafinil may also modestly induce CYP3A4, which has uncertain effect on flurazepam metabolites.
What to do
Reassess the need for both agents and avoid using modafinil to mask sedation; counsel about residual impairment when driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Frequently asked questions
Can I take Flurazepam with Modafinil?
MediHelp rates the interaction as moderate. Flurazepam and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam is a long-acting sedative-hypnotic whose effects oppose the wakefulness promotion of modafinil. Modafinil is not a reliable antidote for benzodiazepine-induced impairment, and the combination makes therapeutic goals conflicting.
How serious is the interaction between Flurazepam and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reassess the need for both agents and avoid using modafinil to mask sedation; counsel about residual impairment when driving.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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