Drug interactions
Flurazepam + Pregabalin
Severity: Major
Flurazepam and Pregabalin: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam and pregabalin together increase sedation and impaired coordination, with a risk of respiratory depression. Flurazepam has long-acting active metabolites, so effects may persist into the next day.
What this interaction means in plain words
Flurazepam and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression through GABAergic benzodiazepine effects and pregabalin.
What to do
Use the lowest effective doses and monitor for daytime sedation and respiratory depression. Consider an alternative hypnotic in the elderly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Flurazepam and Pregabalin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
- Alzain 100 mg Capsules, Hard - SmPC sections 4.3/4.5 (class statement: other central nervous system (CNS) depressant medicinal products; "there are reports of respiratory failure, coma and deaths in patients taking pregabalin and opioids and/or other central nervous system (CNS) depressant medicin") — electronic medicines compendium (UK SmPC)
Other interactions of Pregabalin
Frequently asked questions
Can I take Flurazepam with Pregabalin?
MediHelp rates the interaction as major. Flurazepam and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Flurazepam and pregabalin together increase sedation and impaired coordination, with a risk of respiratory depression. Flurazepam has long-acting active metabolites, so effects may persist into the next day.
How serious is the interaction between Flurazepam and Pregabalin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for daytime sedation and respiratory depression. Consider an alternative hypnotic in the elderly.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
