Drug interactions
Flurazepam + Sevoflurane
Severity: Moderate
Flurazepam and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam has long-acting active metabolites and adds to the CNS depressant effect of sevoflurane. This can produce deeper anesthesia, prolonged sedation and respiratory depression after surgery.
What this interaction means in plain words
Flurazepam and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive GABA-A mediated CNS depression.
What to do
Reduce anesthetic dosing according to clinical response and monitor respiration and sedation level during recovery. Be particularly careful in older patients because of the prolonged effects of the metabolites.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Flurazepam with Sevoflurane?
MediHelp rates the interaction as moderate. Flurazepam and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam has long-acting active metabolites and adds to the CNS depressant effect of sevoflurane. This can produce deeper anesthesia, prolonged sedation and respiratory depression after surgery.
How serious is the interaction between Flurazepam and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce anesthetic dosing according to clinical response and monitor respiration and sedation level during recovery. Be particularly careful in older patients because of the prolonged effects of the metabolites.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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