Drug interactions
Flurbiprofen + Fluvoxamine
Severity: Moderate
Flurbiprofen and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine impairs platelet serotonin uptake, and combined with an NSAID this increases the risk of GI bleeding. Fluvoxamine also inhibits CYP2C9 and may raise flurbiprofen levels.
What this interaction means in plain words
Flurbiprofen and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Fluvoxamine belongs to Central Nervous System.
Why it happens
Additive platelet dysfunction with NSAID mucosal injury, plus fluvoxamine inhibition of CYP2C9.
What to do
Consider gastroprotection in at-risk patients and use the lowest effective flurbiprofen dose. Monitor for bleeding and NSAID adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Flurbiprofen with Fluvoxamine?
MediHelp rates the interaction as moderate. Flurbiprofen and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine impairs platelet serotonin uptake, and combined with an NSAID this increases the risk of GI bleeding. Fluvoxamine also inhibits CYP2C9 and may raise flurbiprofen levels.
How serious is the interaction between Flurbiprofen and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider gastroprotection in at-risk patients and use the lowest effective flurbiprofen dose. Monitor for bleeding and NSAID adverse effects.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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