Drug interactions
Flurbiprofen + Fondaparinux
Severity: Major
Flurbiprofen and Fondaparinux: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fondaparinux is a selective factor Xa inhibitor, and NSAIDs such as flurbiprofen impair platelet function and can injure the GI mucosa. Concomitant use increases the risk of clinically important bleeding.
What this interaction means in plain words
Flurbiprofen and Fondaparinux can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flurbiprofen belongs to Musculoskeletal; Fondaparinux belongs to Cardiovascular.
Why it happens
Additive hemostatic impairment from indirect factor Xa inhibition plus NSAID antiplatelet effect and mucosal injury.
What to do
Avoid concurrent NSAID use if possible and choose paracetamol for analgesia. If combined, monitor hemoglobin and for signs of bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Frequently asked questions
Can I take Flurbiprofen with Fondaparinux?
MediHelp rates the interaction as major. Flurbiprofen and Fondaparinux can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fondaparinux is a selective factor Xa inhibitor, and NSAIDs such as flurbiprofen impair platelet function and can injure the GI mucosa. Concomitant use increases the risk of clinically important bleeding.
How serious is the interaction between Flurbiprofen and Fondaparinux?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent NSAID use if possible and choose paracetamol for analgesia. If combined, monitor hemoglobin and for signs of bleeding.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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