Drug interactions
Flurbiprofen + Furosemide
Severity: Moderate
Flurbiprofen and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs reduce the diuretic and natriuretic response to loop diuretics and may blunt their antihypertensive effect. In volume-depleted or susceptible patients the combination can also increase the risk of acute kidney injury.
What this interaction means in plain words
Flurbiprofen and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Furosemide belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and sodium excretion, antagonizing loop diuretic action.
What to do
Monitor diuretic response, weight, blood pressure and renal function, and increase the furosemide dose if needed. Avoid the combination in dehydration or advanced renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Flurbiprofen with Furosemide?
MediHelp rates the interaction as moderate. Flurbiprofen and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs reduce the diuretic and natriuretic response to loop diuretics and may blunt their antihypertensive effect. In volume-depleted or susceptible patients the combination can also increase the risk of acute kidney injury.
How serious is the interaction between Flurbiprofen and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor diuretic response, weight, blood pressure and renal function, and increase the furosemide dose if needed. Avoid the combination in dehydration or advanced renal impairment.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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