Drug interactions
Flurbiprofen + Gemifloxacin
Severity: Moderate
Flurbiprofen and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones lower the seizure threshold, and NSAIDs may enhance this effect. Seizures are uncommon but can be serious, particularly in patients with epilepsy, renal impairment or CNS disease.
What this interaction means in plain words
Flurbiprofen and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolone antagonism at GABA-A receptors, possibly potentiated by NSAIDs; the exact mechanism is not established.
What to do
Avoid the combination in patients with seizure risk factors and use an alternative analgesic or antibiotic if feasible. Counsel patients to report tremor, confusion or seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Flurbiprofen with Gemifloxacin?
MediHelp rates the interaction as moderate. Flurbiprofen and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones lower the seizure threshold, and NSAIDs may enhance this effect. Seizures are uncommon but can be serious, particularly in patients with epilepsy, renal impairment or CNS disease.
How serious is the interaction between Flurbiprofen and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with seizure risk factors and use an alternative analgesic or antibiotic if feasible. Counsel patients to report tremor, confusion or seizures.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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