Drug interactions
Flurbiprofen + Gentamicin
Severity: Moderate
Flurbiprofen and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal clearance of aminoglycosides, which may raise gentamicin concentrations and increase the risk of nephrotoxicity and ototoxicity. The effect is best documented in neonates but is a concern in patients with reduced renal function.
What this interaction means in plain words
Flurbiprofen and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Gentamicin belongs to Anti Bacterial.
Why it happens
NSAID-induced reduction in renal blood flow and glomerular filtration decreases aminoglycoside elimination, with additive nephrotoxic potential.
What to do
Monitor serum gentamicin concentrations and creatinine, and adjust the gentamicin dose accordingly. Avoid the NSAID where possible in patients with renal impairment or dehydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Flurbiprofen with Gentamicin?
MediHelp rates the interaction as moderate. Flurbiprofen and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal clearance of aminoglycosides, which may raise gentamicin concentrations and increase the risk of nephrotoxicity and ototoxicity. The effect is best documented in neonates but is a concern in patients with reduced renal function.
How serious is the interaction between Flurbiprofen and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum gentamicin concentrations and creatinine, and adjust the gentamicin dose accordingly. Avoid the NSAID where possible in patients with renal impairment or dehydration.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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