Drug interactions
Flurbiprofen + Hydrochlorothiazide-lisinopril
Severity: Major
Flurbiprofen and Hydrochlorothiazide-lisinopril: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen can blunt the blood pressure control of this combination and, with a diuretic and ACE inhibitor, increases the risk of acute kidney injury and hyperkalemia. The risk is greatest in older, dehydrated or renally impaired patients.
What this interaction means in plain words
Flurbiprofen and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flurbiprofen belongs to Musculoskeletal; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion.
What to do
Avoid regular use where possible, or use the lowest dose for the shortest time. Monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Flurbiprofen 100 mg coated tablets - SmPC sections 4.3/4.5 (class statement: ACE inhibitors; "Diuretics, ACE inhibitors and Angiotensin II Antagonists:") — electronic medicines compendium (UK SmPC)
Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as major. Flurbiprofen and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Flurbiprofen can blunt the blood pressure control of this combination and, with a diuretic and ACE inhibitor, increases the risk of acute kidney injury and hyperkalemia. The risk is greatest in older, dehydrated or renally impaired patients.
How serious is the interaction between Flurbiprofen and Hydrochlorothiazide-lisinopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use where possible, or use the lowest dose for the shortest time. Monitor blood pressure, creatinine and potassium.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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