Drug interactions
Flurbiprofen + Labetalol
Severity: Moderate
Flurbiprofen and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen may blunt the blood pressure lowering effect of labetalol, especially with sustained NSAID use. The loss of control is usually modest but can be meaningful in hypertensive patients.
What this interaction means in plain words
Flurbiprofen and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Labetalol belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandins and sodium and water retention counteract the antihypertensive effect.
What to do
Monitor blood pressure when NSAID therapy is started or continued beyond a short course, and adjust antihypertensive dosing if needed. Use the lowest NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Flurbiprofen with Labetalol?
MediHelp rates the interaction as moderate. Flurbiprofen and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurbiprofen may blunt the blood pressure lowering effect of labetalol, especially with sustained NSAID use. The loss of control is usually modest but can be meaningful in hypertensive patients.
How serious is the interaction between Flurbiprofen and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when NSAID therapy is started or continued beyond a short course, and adjust antihypertensive dosing if needed. Use the lowest NSAID dose for the shortest duration.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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