Drug interactions
Flurbiprofen + Levomilnacipran
Severity: Moderate
Flurbiprofen and Levomilnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SNRIs reduce platelet serotonin uptake and impair platelet aggregation, and NSAIDs add antiplatelet effects and gastric mucosal injury. Together they increase the risk of bleeding, especially upper gastrointestinal bleeding.
What this interaction means in plain words
Flurbiprofen and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Levomilnacipran belongs to Central Nervous System.
Why it happens
Additive impairment of platelet function (serotonin depletion plus COX inhibition) with NSAID mucosal damage.
What to do
Monitor for gastrointestinal bleeding and consider gastroprotection with a proton pump inhibitor in high-risk patients. Prefer non-NSAID analgesia when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Flurbiprofen with Levomilnacipran?
MediHelp rates the interaction as moderate. Flurbiprofen and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SNRIs reduce platelet serotonin uptake and impair platelet aggregation, and NSAIDs add antiplatelet effects and gastric mucosal injury. Together they increase the risk of bleeding, especially upper gastrointestinal bleeding.
How serious is the interaction between Flurbiprofen and Levomilnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal bleeding and consider gastroprotection with a proton pump inhibitor in high-risk patients. Prefer non-NSAID analgesia when possible.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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