Drug interactions
Flurbiprofen + Lornoxicam
Severity: Major
Flurbiprofen and Lornoxicam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two NSAIDs together increases the risk of gastrointestinal ulceration and bleeding, renal injury and cardiovascular events without improving pain relief.
What this interaction means in plain words
Flurbiprofen and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flurbiprofen belongs to Musculoskeletal; Lornoxicam belongs to Musculoskeletal.
Why it happens
Additive cyclooxygenase inhibition causing cumulative gastrointestinal, platelet and renal effects.
What to do
Avoid combining systemic NSAIDs; use one agent at the lowest effective dose. Add paracetamol or another non-NSAID analgesic if needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Flurbiprofen with Lornoxicam?
MediHelp rates the interaction as major. Flurbiprofen and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using two NSAIDs together increases the risk of gastrointestinal ulceration and bleeding, renal injury and cardiovascular events without improving pain relief.
How serious is the interaction between Flurbiprofen and Lornoxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining systemic NSAIDs; use one agent at the lowest effective dose. Add paracetamol or another non-NSAID analgesic if needed.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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