Drug interactions
Flurbiprofen + Losartan
Severity: Moderate
Flurbiprofen and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen can reduce the antihypertensive effect of losartan, and the pair raises the risk of acute kidney injury and hyperkalemia, especially in elderly, volume-depleted or renally impaired patients.
What this interaction means in plain words
Flurbiprofen and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Losartan belongs to Cardiovascular.
Why it happens
NSAIDs reduce vasodilatory renal prostaglandins while ARBs reduce efferent arteriolar tone, lowering glomerular filtration and potassium excretion.
What to do
Monitor blood pressure, creatinine and potassium after initiation and maintain hydration. Avoid prolonged combined use in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Flurbiprofen with Losartan?
MediHelp rates the interaction as moderate. Flurbiprofen and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurbiprofen can reduce the antihypertensive effect of losartan, and the pair raises the risk of acute kidney injury and hyperkalemia, especially in elderly, volume-depleted or renally impaired patients.
How serious is the interaction between Flurbiprofen and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium after initiation and maintain hydration. Avoid prolonged combined use in high-risk patients.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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