Drug interactions
Flurbiprofen + Moxifloxacin
Severity: Moderate
Flurbiprofen and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinolone antibiotics can provoke CNS stimulation and convulsions, and concurrent NSAID use may raise this risk. The risk is greatest in patients with prior seizures or other CNS risk factors.
What this interaction means in plain words
Flurbiprofen and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolone inhibition of GABA-A receptor binding is potentiated by NSAIDs, lowering the seizure threshold.
What to do
Avoid in patients with epilepsy or a history of seizures and consider an alternative antibiotic. Otherwise monitor for neurological symptoms and stop the quinolone if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Flurbiprofen with Moxifloxacin?
MediHelp rates the interaction as moderate. Flurbiprofen and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinolone antibiotics can provoke CNS stimulation and convulsions, and concurrent NSAID use may raise this risk. The risk is greatest in patients with prior seizures or other CNS risk factors.
How serious is the interaction between Flurbiprofen and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with epilepsy or a history of seizures and consider an alternative antibiotic. Otherwise monitor for neurological symptoms and stop the quinolone if they occur.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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