Drug interactions
Flurbiprofen + Ospemifene
Severity: Minor
Flurbiprofen and Ospemifene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen is a CYP2C9 substrate and ospemifene is metabolized partly by CYP2C9, CYP3A4 and CYP2C19. Any effect of flurbiprofen on ospemifene exposure is theoretical and unlikely to be clinically important.
What this interaction means in plain words
Flurbiprofen and Ospemifene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Flurbiprofen belongs to Musculoskeletal; Ospemifene belongs to Endocrine.
Why it happens
Possible competition for CYP2C9 metabolism, not established as clinically significant.
What to do
No routine action is needed; use ospemifene at the usual dose and review if unexpected adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
Frequently asked questions
Can I take Flurbiprofen with Ospemifene?
MediHelp rates the interaction as minor. Flurbiprofen and Ospemifene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Flurbiprofen is a CYP2C9 substrate and ospemifene is metabolized partly by CYP2C9, CYP3A4 and CYP2C19. Any effect of flurbiprofen on ospemifene exposure is theoretical and unlikely to be clinically important.
How serious is the interaction between Flurbiprofen and Ospemifene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; use ospemifene at the usual dose and review if unexpected adverse effects occur.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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