Drug interactions
Flurbiprofen + Pegaspargase
Severity: Moderate
Flurbiprofen and Pegaspargase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegaspargase can cause coagulopathy through reduced synthesis of clotting factors and can lower fibrinogen, and it is associated with thrombocytopenia in some settings. Flurbiprofen inhibits platelet function and irritates the gastric mucosa, so bleeding risk may be increased.
What this interaction means in plain words
Flurbiprofen and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Pegaspargase belongs to Oncology.
Why it happens
Additive hemostatic impairment: asparaginase-related clotting factor depletion plus NSAID antiplatelet effect.
What to do
Avoid NSAIDs where possible during pegaspargase therapy; if needed, monitor platelet count, fibrinogen and coagulation parameters and watch for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Pegaspargase
- Etodolac + Pegaspargase Major
- Ketorolac + Pegaspargase Major
- Mefenamic acid + Pegaspargase Major
- Acetylsalicylic acid + Pegaspargase Moderate
- Argatroban + Pegaspargase Moderate
- Celecoxib + Pegaspargase Moderate
Frequently asked questions
Can I take Flurbiprofen with Pegaspargase?
MediHelp rates the interaction as moderate. Flurbiprofen and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegaspargase can cause coagulopathy through reduced synthesis of clotting factors and can lower fibrinogen, and it is associated with thrombocytopenia in some settings. Flurbiprofen inhibits platelet function and irritates the gastric mucosa, so bleeding risk may be increased.
How serious is the interaction between Flurbiprofen and Pegaspargase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible during pegaspargase therapy; if needed, monitor platelet count, fibrinogen and coagulation parameters and watch for bleeding.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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