Drug interactions
Flurbiprofen + Voriconazole
Severity: Moderate
Flurbiprofen and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP2C9 and can increase flurbiprofen concentrations, as seen with other CYP2C9 substrate NSAIDs. This may increase gastrointestinal, renal and cardiovascular adverse effects.
What this interaction means in plain words
Flurbiprofen and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP2C9, reducing hepatic metabolism of flurbiprofen.
What to do
Monitor for NSAID toxicity and consider reducing the flurbiprofen dose during voriconazole treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Flurbiprofen with Voriconazole?
MediHelp rates the interaction as moderate. Flurbiprofen and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP2C9 and can increase flurbiprofen concentrations, as seen with other CYP2C9 substrate NSAIDs. This may increase gastrointestinal, renal and cardiovascular adverse effects.
How serious is the interaction between Flurbiprofen and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for NSAID toxicity and consider reducing the flurbiprofen dose during voriconazole treatment.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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