Drug interactions
Flutamide + Mitotane
Severity: Moderate
Flutamide and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a potent inducer of CYP3A4 and may lower exposure to flutamide and its active metabolite. This could reduce antiandrogen efficacy.
What this interaction means in plain words
Flutamide and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flutamide belongs to Endocrine; Mitotane belongs to Oncology.
Why it happens
Mitotane induces CYP3A4 and other hepatic enzymes, accelerating the metabolism of flutamide.
What to do
Monitor clinical and PSA response to flutamide and consider an alternative antiandrogen if response is lost. Monitor liver function, as increased metabolite formation may also matter.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flutamide
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Flutamide with Mitotane?
MediHelp rates the interaction as moderate. Flutamide and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a potent inducer of CYP3A4 and may lower exposure to flutamide and its active metabolite. This could reduce antiandrogen efficacy.
How serious is the interaction between Flutamide and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical and PSA response to flutamide and consider an alternative antiandrogen if response is lost. Monitor liver function, as increased metabolite formation may also matter.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
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