Drug interactions
Flutamide + Voxelotor
Severity: Moderate
Flutamide and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and could increase flutamide exposure. This may raise the risk of flutamide-related liver toxicity.
What this interaction means in plain words
Flutamide and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flutamide belongs to Endocrine; Voxelotor belongs to Miscellaneous.
Why it happens
CYP3A4 inhibition by voxelotor reduces flutamide metabolism.
What to do
Monitor liver function tests during combined use. Consider an alternative if abnormalities develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flutamide
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Flutamide with Voxelotor?
MediHelp rates the interaction as moderate. Flutamide and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 and could increase flutamide exposure. This may raise the risk of flutamide-related liver toxicity.
How serious is the interaction between Flutamide and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests during combined use. Consider an alternative if abnormalities develop.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
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