Drug interactions
Fluticasone + Imatinib
Severity: Moderate
Fluticasone and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib is a moderate CYP3A4 inhibitor and may increase fluticasone exposure. The clinical effect is probably smaller than with strong inhibitors, but systemic corticosteroid effects are possible with long-term use.
What this interaction means in plain words
Fluticasone and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone belongs to Respiratory; Imatinib belongs to Oncology.
Why it happens
Imatinib inhibits CYP3A4, reducing fluticasone metabolism.
What to do
Monitor for signs of systemic corticosteroid excess such as Cushingoid features. Use the lowest effective fluticasone dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Fluticasone with Imatinib?
MediHelp rates the interaction as moderate. Fluticasone and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib is a moderate CYP3A4 inhibitor and may increase fluticasone exposure. The clinical effect is probably smaller than with strong inhibitors, but systemic corticosteroid effects are possible with long-term use.
How serious is the interaction between Fluticasone and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of systemic corticosteroid excess such as Cushingoid features. Use the lowest effective fluticasone dose.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
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