Drug interactions
Fluticasone + Mifepristone
Severity: Moderate
Fluticasone and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may raise fluticasone systemic exposure. In addition, mifepristone blocks glucocorticoid receptors, which may blunt the effect of corticosteroid therapy.
What this interaction means in plain words
Fluticasone and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone belongs to Respiratory; Mifepristone belongs to Endocrine.
Why it happens
CYP3A4 inhibition by mifepristone plus glucocorticoid receptor antagonism.
What to do
Monitor for loss of asthma control and for systemic corticosteroid effects, and adjust the fluticasone dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluticasone and Mifepristone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluticasone
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Fluticasone with Mifepristone?
MediHelp rates the interaction as moderate. Fluticasone and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may raise fluticasone systemic exposure. In addition, mifepristone blocks glucocorticoid receptors, which may blunt the effect of corticosteroid therapy.
How serious is the interaction between Fluticasone and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of asthma control and for systemic corticosteroid effects, and adjust the fluticasone dose according to response.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
