Drug interactions
Fluticasone + Mitotane
Severity: Moderate
Fluticasone and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a potent CYP3A4 inducer and can substantially lower fluticasone levels. Mitotane also causes adrenal insufficiency, which complicates corticosteroid management.
What this interaction means in plain words
Fluticasone and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone belongs to Respiratory; Mitotane belongs to Oncology.
Why it happens
Mitotane induces CYP3A4, increasing fluticasone metabolism.
What to do
Monitor for loss of asthma or allergy control and adjust fluticasone dose accordingly. Be alert to adrenal insufficiency on mitotane.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Fluticasone with Mitotane?
MediHelp rates the interaction as moderate. Fluticasone and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a potent CYP3A4 inducer and can substantially lower fluticasone levels. Mitotane also causes adrenal insufficiency, which complicates corticosteroid management.
How serious is the interaction between Fluticasone and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of asthma or allergy control and adjust fluticasone dose accordingly. Be alert to adrenal insufficiency on mitotane.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
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