Drug interactions
Fluticasone + Quinidine
Severity: Minor
Fluticasone and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a CYP3A4 substrate and weak inhibitor, and a meaningful effect on fluticasone exposure is not well established. Any clinically relevant increase in corticosteroid effect is expected to be small.
What this interaction means in plain words
Fluticasone and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone belongs to Respiratory; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine may weakly inhibit CYP3A4, though an effect on fluticasone is not firmly established.
What to do
No specific action is usually required. Watch for signs of systemic corticosteroid excess during prolonged use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Fluticasone with Quinidine?
MediHelp rates the interaction as minor. Fluticasone and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinidine is a CYP3A4 substrate and weak inhibitor, and a meaningful effect on fluticasone exposure is not well established. Any clinically relevant increase in corticosteroid effect is expected to be small.
How serious is the interaction between Fluticasone and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is usually required. Watch for signs of systemic corticosteroid excess during prolonged use.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
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