Drug interactions
Fluticasone furoate + Idelalisib
Severity: Moderate
Fluticasone furoate and Idelalisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A4 inhibitor and can raise systemic fluticasone furoate levels. This may cause systemic corticosteroid effects such as adrenal suppression and Cushingoid features, particularly with prolonged use.
What this interaction means in plain words
Fluticasone furoate and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Idelalisib inhibits CYP3A4, reducing the clearance of fluticasone furoate.
What to do
Monitor for signs of corticosteroid excess and adrenal suppression with prolonged co-use; consider an alternative corticosteroid such as beclomethasone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Fluticasone furoate with Idelalisib?
MediHelp rates the interaction as moderate. Fluticasone furoate and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A4 inhibitor and can raise systemic fluticasone furoate levels. This may cause systemic corticosteroid effects such as adrenal suppression and Cushingoid features, particularly with prolonged use.
How serious is the interaction between Fluticasone furoate and Idelalisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess and adrenal suppression with prolonged co-use; consider an alternative corticosteroid such as beclomethasone.
What other medicines interact with Idelalisib?
MediHelp also lists interactions of Idelalisib with, for example, Alfuzosin, Cisapride, Dihydroergotamine. The full list is on the Idelalisib page.
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