Drug interactions
Fluticasone furoate + Levoketoconazole
Severity: Major
Fluticasone furoate and Levoketoconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and can substantially raise fluticasone furoate exposure. This may result in systemic corticosteroid effects including adrenal suppression, a concern since levoketoconazole itself lowers cortisol.
What this interaction means in plain words
Fluticasone furoate and Levoketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Levoketoconazole strongly inhibits CYP3A4, blocking fluticasone clearance.
What to do
Avoid long-term co-use where possible and switch to a less CYP3A4-dependent corticosteroid such as beclomethasone; otherwise monitor for Cushingoid features and adrenal insufficiency.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluticasone furoate and Levoketoconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Fluticasone furoate with Levoketoconazole?
MediHelp rates the interaction as major. Fluticasone furoate and Levoketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levoketoconazole is a strong CYP3A4 inhibitor and can substantially raise fluticasone furoate exposure. This may result in systemic corticosteroid effects including adrenal suppression, a concern since levoketoconazole itself lowers cortisol.
How serious is the interaction between Fluticasone furoate and Levoketoconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term co-use where possible and switch to a less CYP3A4-dependent corticosteroid such as beclomethasone; otherwise monitor for Cushingoid features and adrenal insufficiency.
What other medicines interact with Levoketoconazole?
MediHelp also lists interactions of Levoketoconazole with, for example, Alfuzosin, Alprazolam, Amiodarone. The full list is on the Levoketoconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
