Drug interactions
Fluticasone furoate + Rucaparib
Severity: Minor
Fluticasone furoate and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak CYP3A4 inhibitor and may modestly raise fluticasone furoate exposure. Clinically significant corticosteroid excess is unlikely with typical inhaled or intranasal doses.
What this interaction means in plain words
Fluticasone furoate and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak inhibition of CYP3A4 by rucaparib reduces fluticasone clearance.
What to do
No routine change is needed; watch for signs of systemic corticosteroid effects with long-term use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Fluticasone furoate with Rucaparib?
MediHelp rates the interaction as minor. Fluticasone furoate and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak CYP3A4 inhibitor and may modestly raise fluticasone furoate exposure. Clinically significant corticosteroid excess is unlikely with typical inhaled or intranasal doses.
How serious is the interaction between Fluticasone furoate and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; watch for signs of systemic corticosteroid effects with long-term use.
What other medicines interact with Rucaparib?
MediHelp also lists interactions of Rucaparib with, for example, Cisapride, Ergotamine, Pimozide. The full list is on the Rucaparib page.
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