Drug interactions
Fluticasone-salmeterol + Furosemide
Severity: Moderate
Fluticasone-salmeterol and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both furosemide and beta-2 agonists lower serum potassium, so combined use can cause clinically significant hypokalemia. This can predispose to arrhythmias, especially with heart disease or digoxin.
What this interaction means in plain words
Fluticasone-salmeterol and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-salmeterol belongs to Respiratory; Furosemide belongs to Cardiovascular.
Why it happens
Additive hypokalemia from renal potassium loss and beta-2-mediated intracellular potassium shift.
What to do
Monitor serum potassium periodically, especially at the start of therapy or with high doses. Replace potassium or add a potassium-sparing agent if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Fluticasone-salmeterol with Furosemide?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both furosemide and beta-2 agonists lower serum potassium, so combined use can cause clinically significant hypokalemia. This can predispose to arrhythmias, especially with heart disease or digoxin.
How serious is the interaction between Fluticasone-salmeterol and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically, especially at the start of therapy or with high doses. Replace potassium or add a potassium-sparing agent if needed.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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