Drug interactions
Fluticasone-salmeterol + Gentamicin
Severity: Minor
Fluticasone-salmeterol and Gentamicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gentamicin can cause renal magnesium and potassium wasting, and salmeterol can lower potassium, so electrolyte depletion is possible. The clinical significance is usually small with inhaled salmeterol.
What this interaction means in plain words
Fluticasone-salmeterol and Gentamicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-salmeterol belongs to Respiratory; Gentamicin belongs to Anti Bacterial.
Why it happens
Additive hypokalemia via aminoglycoside renal tubular wasting and beta-2-mediated potassium shift.
What to do
Monitor potassium and magnesium during prolonged or high-dose gentamicin therapy and replace as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Fluticasone-salmeterol with Gentamicin?
MediHelp rates the interaction as minor. Fluticasone-salmeterol and Gentamicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gentamicin can cause renal magnesium and potassium wasting, and salmeterol can lower potassium, so electrolyte depletion is possible. The clinical significance is usually small with inhaled salmeterol.
How serious is the interaction between Fluticasone-salmeterol and Gentamicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and magnesium during prolonged or high-dose gentamicin therapy and replace as needed.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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