Drug interactions
Fluticasone-salmeterol + Gilteritinib
Severity: Moderate
Fluticasone-salmeterol and Gilteritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib is associated with QT prolongation and torsades risk, and salmeterol may add to this effect, especially if it lowers potassium. The combination raises the chance of ventricular arrhythmia.
What this interaction means in plain words
Fluticasone-salmeterol and Gilteritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-salmeterol belongs to Respiratory; Gilteritinib belongs to Oncology.
Why it happens
Additive QT prolongation, with beta2-agonist-induced hypokalemia as a further contributor.
What to do
Obtain ECGs and check electrolytes before and during combined use, correcting potassium and magnesium abnormalities. Reduce or withhold gilteritinib per labeling if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Fluticasone-salmeterol with Gilteritinib?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Gilteritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib is associated with QT prolongation and torsades risk, and salmeterol may add to this effect, especially if it lowers potassium. The combination raises the chance of ventricular arrhythmia.
How serious is the interaction between Fluticasone-salmeterol and Gilteritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECGs and check electrolytes before and during combined use, correcting potassium and magnesium abnormalities. Reduce or withhold gilteritinib per labeling if QTc becomes markedly prolonged.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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