Drug interactions
Fluticasone-salmeterol + Iloperidone
Severity: Moderate
Fluticasone-salmeterol and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone can inhibit CYP3A4 and may raise salmeterol exposure, increasing beta-agonist effects such as tachycardia, tremor and QT prolongation. Iloperidone itself prolongs the QT interval, adding to cardiac risk.
What this interaction means in plain words
Fluticasone-salmeterol and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-salmeterol belongs to Respiratory; Iloperidone belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition by iloperidone raises salmeterol levels, plus additive QT prolongation.
What to do
Monitor heart rate and ECG in patients with cardiac risk factors, and watch for beta-agonist adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Fluticasone-salmeterol with Iloperidone?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone can inhibit CYP3A4 and may raise salmeterol exposure, increasing beta-agonist effects such as tachycardia, tremor and QT prolongation. Iloperidone itself prolongs the QT interval, adding to cardiac risk.
How serious is the interaction between Fluticasone-salmeterol and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG in patients with cardiac risk factors, and watch for beta-agonist adverse effects.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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