Drug interactions
Fluticasone-salmeterol + Labetalol
Severity: Major
Fluticasone-salmeterol and Labetalol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol blocks beta-adrenergic receptors and can oppose the bronchodilator effect of salmeterol. In patients with asthma or COPD this may cause bronchospasm and reduced control of symptoms.
What this interaction means in plain words
Fluticasone-salmeterol and Labetalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-salmeterol belongs to Respiratory; Labetalol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors by labetalol (nonselective beta blockade plus alpha blockade).
What to do
Avoid labetalol in patients with asthma or significant reactive airway disease and choose an alternative antihypertensive. If unavoidable, monitor respiratory status and peak flow closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Fluticasone-salmeterol with Labetalol?
MediHelp rates the interaction as major. Fluticasone-salmeterol and Labetalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Labetalol blocks beta-adrenergic receptors and can oppose the bronchodilator effect of salmeterol. In patients with asthma or COPD this may cause bronchospasm and reduced control of symptoms.
How serious is the interaction between Fluticasone-salmeterol and Labetalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid labetalol in patients with asthma or significant reactive airway disease and choose an alternative antihypertensive. If unavoidable, monitor respiratory status and peak flow closely.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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