Drug interactions
Fluticasone-salmeterol + Letermovir
Severity: Moderate
Fluticasone-salmeterol and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir is a moderate CYP3A inhibitor and may raise systemic exposure to salmeterol and fluticasone. Higher salmeterol levels can cause tachycardia, tremor and QT prolongation, and higher fluticasone levels may cause systemic corticosteroid effects.
What this interaction means in plain words
Fluticasone-salmeterol and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-salmeterol belongs to Respiratory; Letermovir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated metabolism of salmeterol and fluticasone.
What to do
Monitor for beta-agonist cardiovascular effects and signs of corticosteroid excess, and consider ECG in at-risk patients. Review need for the combination during prolonged letermovir therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Fluticasone-salmeterol with Letermovir?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir is a moderate CYP3A inhibitor and may raise systemic exposure to salmeterol and fluticasone. Higher salmeterol levels can cause tachycardia, tremor and QT prolongation, and higher fluticasone levels may cause systemic corticosteroid effects.
How serious is the interaction between Fluticasone-salmeterol and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for beta-agonist cardiovascular effects and signs of corticosteroid excess, and consider ECG in at-risk patients. Review need for the combination during prolonged letermovir therapy.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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