Drug interactions
Fluticasone-salmeterol + Mefloquine
Severity: Moderate
Fluticasone-salmeterol and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine can alter cardiac conduction and prolong the QT interval, and salmeterol may contribute to QT prolongation and hypokalemia. Combined use may increase arrhythmia risk.
What this interaction means in plain words
Fluticasone-salmeterol and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-salmeterol belongs to Respiratory; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia.
What to do
Obtain a baseline ECG and correct potassium and magnesium. Consider alternative antimalarial prophylaxis in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Mefloquine?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine can alter cardiac conduction and prolong the QT interval, and salmeterol may contribute to QT prolongation and hypokalemia. Combined use may increase arrhythmia risk.
How serious is the interaction between Fluticasone-salmeterol and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium. Consider alternative antimalarial prophylaxis in patients with QT risk factors.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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