Drug interactions
Fluticasone-salmeterol + Osilodrostat
Severity: Moderate
Fluticasone-salmeterol and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and salmeterol can also lower potassium. Combination may increase the risk of torsades de pointes, particularly with electrolyte disturbance or cardiac disease.
What this interaction means in plain words
Fluticasone-salmeterol and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-salmeterol belongs to Respiratory; Osilodrostat belongs to Endocrine.
Why it happens
Additive QT prolongation, compounded by beta-2 mediated hypokalemia.
What to do
Obtain a baseline ECG and monitor QTc after starting or adjusting either drug. Correct potassium and magnesium before and during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Fluticasone-salmeterol with Osilodrostat?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and salmeterol can also lower potassium. Combination may increase the risk of torsades de pointes, particularly with electrolyte disturbance or cardiac disease.
How serious is the interaction between Fluticasone-salmeterol and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc after starting or adjusting either drug. Correct potassium and magnesium before and during therapy.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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