Drug interactions
Fluticasone-salmeterol + Ribociclib
Severity: Moderate
Fluticasone-salmeterol and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor and may raise systemic fluticasone exposure, although inhaled fluticasone has very low baseline bioavailability. Ribociclib also prolongs the QT interval, and salmeterol can add to this effect at higher exposures.
What this interaction means in plain words
Fluticasone-salmeterol and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-salmeterol belongs to Respiratory; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing metabolism of fluticasone and salmeterol, with additive QT-prolonging potential.
What to do
Monitor for corticosteroid systemic effects such as adrenal suppression with prolonged use, and review ECG and electrolytes as per ribociclib monitoring. Report palpitations or syncope promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Ribociclib?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate CYP3A4 inhibitor and may raise systemic fluticasone exposure, although inhaled fluticasone has very low baseline bioavailability. Ribociclib also prolongs the QT interval, and salmeterol can add to this effect at higher exposures.
How serious is the interaction between Fluticasone-salmeterol and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid systemic effects such as adrenal suppression with prolonged use, and review ECG and electrolytes as per ribociclib monitoring. Report palpitations or syncope promptly.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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