Drug interactions
Fluticasone-salmeterol + Succinylcholine
Severity: Minor
Fluticasone-salmeterol and Succinylcholine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Succinylcholine can raise serum potassium, whereas salmeterol tends to lower it, so effects may partly offset. Beta-agonists can also contribute to arrhythmia risk during anesthesia, but no important interaction is established.
What this interaction means in plain words
Fluticasone-salmeterol and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-salmeterol belongs to Respiratory; Succinylcholine belongs to Musculoskeletal.
Why it happens
Opposing effects on serum potassium and possible additive adrenergic arrhythmia risk; not well established.
What to do
Continue inhaled therapy perioperatively as usual and monitor potassium and ECG as part of routine anesthetic care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Succinylcholine
Frequently asked questions
Can I take Fluticasone-salmeterol with Succinylcholine?
MediHelp rates the interaction as minor. Fluticasone-salmeterol and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Succinylcholine can raise serum potassium, whereas salmeterol tends to lower it, so effects may partly offset. Beta-agonists can also contribute to arrhythmia risk during anesthesia, but no important interaction is established.
How serious is the interaction between Fluticasone-salmeterol and Succinylcholine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue inhaled therapy perioperatively as usual and monitor potassium and ECG as part of routine anesthetic care.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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