Drug interactions
Fluticasone-salmeterol + Tapentadol
Severity: Minor
Fluticasone-salmeterol and Tapentadol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tapentadol causes sedation and respiratory depression, which is relevant in patients with severe asthma or COPD. Salmeterol does not counteract these effects, and the interaction is mainly the underlying respiratory disease risk.
What this interaction means in plain words
Fluticasone-salmeterol and Tapentadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-salmeterol belongs to Respiratory; Tapentadol belongs to Musculoskeletal.
Why it happens
No true pharmacological interaction; opioid respiratory depression may matter in patients with chronic airway disease.
What to do
Use the lowest effective tapentadol dose in patients with severe COPD or asthma and monitor respiratory status.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Tapentadol?
MediHelp rates the interaction as minor. Fluticasone-salmeterol and Tapentadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tapentadol causes sedation and respiratory depression, which is relevant in patients with severe asthma or COPD. Salmeterol does not counteract these effects, and the interaction is mainly the underlying respiratory disease risk.
How serious is the interaction between Fluticasone-salmeterol and Tapentadol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective tapentadol dose in patients with severe COPD or asthma and monitor respiratory status.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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