Drug interactions
Fluticasone-salmeterol + Tazemetostat
Severity: Minor
Fluticasone-salmeterol and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak to moderate CYP3A4 inducer and may lower exposure to CYP3A4 substrates such as fluticasone and salmeterol. This could reduce asthma or COPD control, although the effect of inhaled doses is probably modest.
What this interaction means in plain words
Fluticasone-salmeterol and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-salmeterol belongs to Respiratory; Tazemetostat belongs to Miscellaneous.
Why it happens
Induction of CYP3A4 by tazemetostat increases metabolism of fluticasone and salmeterol.
What to do
Monitor respiratory symptom control and adjust inhaled therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Fluticasone-salmeterol with Tazemetostat?
MediHelp rates the interaction as minor. Fluticasone-salmeterol and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak to moderate CYP3A4 inducer and may lower exposure to CYP3A4 substrates such as fluticasone and salmeterol. This could reduce asthma or COPD control, although the effect of inhaled doses is probably modest.
How serious is the interaction between Fluticasone-salmeterol and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory symptom control and adjust inhaled therapy if control worsens.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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