Drug interactions
Fluticasone-salmeterol + Tipranavir
Severity: Major
Fluticasone-salmeterol and Tipranavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir is given with ritonavir, which strongly inhibits CYP3A4 and can greatly raise fluticasone exposure, with Cushing's syndrome and adrenal suppression reported for this class. Salmeterol exposure and QT risk may also rise.
What this interaction means in plain words
Fluticasone-salmeterol and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-salmeterol belongs to Respiratory; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted CYP3A4 inhibition reduces metabolism of fluticasone and salmeterol.
What to do
Avoid the combination if possible and switch to an alternative inhaled corticosteroid such as beclomethasone. If it cannot be avoided, monitor for corticosteroid excess and cardiac effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Tipranavir?
MediHelp rates the interaction as major. Fluticasone-salmeterol and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir is given with ritonavir, which strongly inhibits CYP3A4 and can greatly raise fluticasone exposure, with Cushing's syndrome and adrenal suppression reported for this class. Salmeterol exposure and QT risk may also rise.
How serious is the interaction between Fluticasone-salmeterol and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and switch to an alternative inhaled corticosteroid such as beclomethasone. If it cannot be avoided, monitor for corticosteroid excess and cardiac effects.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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