Drug interactions
Fluticasone-salmeterol + Torsemide
Severity: Moderate
Fluticasone-salmeterol and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both salmeterol and loop diuretics can lower serum potassium, so the combination may increase hypokalemia and arrhythmia risk, mainly with high doses or underlying heart disease.
What this interaction means in plain words
Fluticasone-salmeterol and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-salmeterol belongs to Respiratory; Torsemide belongs to Cardiovascular.
Why it happens
Additive hypokalemia from beta2-mediated intracellular potassium shift and renal potassium loss.
What to do
Monitor serum potassium and magnesium, especially in patients with cardiac disease or on other QT-prolonging drugs, and supplement as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Torsemide
Frequently asked questions
Can I take Fluticasone-salmeterol with Torsemide?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both salmeterol and loop diuretics can lower serum potassium, so the combination may increase hypokalemia and arrhythmia risk, mainly with high doses or underlying heart disease.
How serious is the interaction between Fluticasone-salmeterol and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, especially in patients with cardiac disease or on other QT-prolonging drugs, and supplement as needed.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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