Drug interactions
Fluticasone-vilanterol + Imatinib
Severity: Minor
Fluticasone-vilanterol and Imatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib is a moderate CYP3A4 inhibitor, and both fluticasone furoate and vilanterol are CYP3A4 substrates. Systemic exposure to the inhaled components may rise slightly, though low oral bioavailability limits the effect, with possible corticosteroid or beta-agonist adverse effects.
What this interaction means in plain words
Fluticasone-vilanterol and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-vilanterol belongs to Respiratory; Imatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of fluticasone furoate and vilanterol, increasing systemic exposure.
What to do
No routine adjustment is required; watch for systemic corticosteroid effects, tremor, tachycardia or hypokalemia during long-term combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-vilanterol
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Fluticasone-vilanterol with Imatinib?
MediHelp rates the interaction as minor. Fluticasone-vilanterol and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib is a moderate CYP3A4 inhibitor, and both fluticasone furoate and vilanterol are CYP3A4 substrates. Systemic exposure to the inhaled components may rise slightly, though low oral bioavailability limits the effect, with possible corticosteroid or beta-agonist adverse effects.
How serious is the interaction between Fluticasone-vilanterol and Imatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; watch for systemic corticosteroid effects, tremor, tachycardia or hypokalemia during long-term combined use.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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